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    A GLIMPSE ON Baccaurea accaurea ramiflora, ramiflora, A LESS APPEALING, UNDERUTILIZED MEDICINAL PLANT OF WEST WEST-BENGAL (AN EXTENSIVE REVIEW)
    (INTERNATIONAL JOURNAL OF CURRENT RESEARCH, 2025-01-04) Dey, Purnima; Pal, Imana
    Baccaurea ramiflora Lour. syn. Baccaurea sapida (Roxb.) Muell. Arg locally known as Latkan or Anshfol is a versatile though underexploited plant with number of health benefits. In West Bengal the fruit plant is grown mainly in homestead condition. It is a mild acidic fruit and mainly consumed fresh. This extensive extensive review encompasses all the available literature with respect to habitat, physical characteristics, ethenomedicinal and traditional uses, physiochemi physiochemical and nutritional composition, active constituents ,therapeutic role which helps to put a glimpse on this underutilized less appealing medicinal plant of West-Bengal.
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    A Review on Lotus (Nelumbo nucifera) Seed
    (International Journal of Science and Researc, 2025-01-04) Pal, Imana; Dey, Purnima
    Nelumbo nucifera or lotus seeds are edible and have been used as a traditional medicine since ages for curing various diseases. The longevity of lotus seed is unique. Researches revealed that it has hepatoprotective, hypoglycemic, immunomodulatory, antianalgesic, antiperkinsonian, antifertility, antidermatophytic, psychopharmacological properties. It can be used as low cost protein and energy supplement. Lotus seed oil is also useful. It is used in different cuisines. This review attempts to cover all the available literature on the seeds of Nelumbo nucifera with respect to its traditional uses, chemical constituents, physicochemical properties, phytoconstituents and summing up of its various physiological, psychological and therapeutic benefits.
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    A stimuli-responsive L-DOPA-based supramolecular gel for the detection of fluoride ion
    (Royal society of chemistry, 2024) Mandal, Subhra Kanti; Seth, Piya; Kar, Tanmoy
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    Active components of tea (Camellia sinensis) extracts and their beneficial application on human health
    (2024-12-30) Seth, Piya; Mandal, Subhra Kanti
    Tea is one of the most frequently consumed beverages across the world and is popular for its classic brew, flavour and wide range of health benefits. The variation in aroma, taste and colour of different kind of teas are caused by the manufacturing process popularly known as fermentation and essentially determine the quality and acceptance of tea flushes. A variety of volatile components such as terpenoids, alcohols, carbonyl compounds, etc. are reported to contribute to the signature tea aromas whereas the non-volatile polyphenolic components (mainly catechins, flavonols, theaflavins, thearubigins), amino acids and xanthines are responsible for the characteristic taste and colour of tea infusions. The nutritional value of tea is mostly gained from the tea polyphenols and amino acids that are reported to possess a broad spectrum of bioactivities, including anti-oxidant properties, reduction of various cancers, inhibition of inflammation and protective effects against diabetes, hyperlipidemia and obesity. Global tea research has generated much in vitro and in vivo data rationally correlating tea polyphenols with their preventive and therapeutic properties against human diseases like cancer, metabolic and cardiovascular diseases etc. Recently, number of studies also suggests that tea polyphenols have the potential to treat or prevent COVID-19 disease. In the current review, we focus on the chemistry behind the signature fragrance, taste and colour of variety of tea and their beneficial account as antioxidant and therapeutic effectiveness against many diseases such as lowering of blood pressure, diabetes, inflammation, anticancer properties and most interestingly against COVID-19 pandemic. Keywords: Tea chemistry, polyphenols, catechins, theaflavins, health benefits, COVID-19.
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    An Extensive Review on Allium ampeloprasum A Magical Herb
    (International Journal of Science and Research, 2025-01-04) Dey, Purnima; Khaled, Kazi Layla
    Allium vegetable has been used as folk medicine since ancient times. Allium genus has over 600 members which differ in maturing, color and taste; however, they are similar in biochemical content. Allium ampeloprasum, is a monocotyledon plant of the lily family (Liliaceae) and belongs to the genus Allium. It has a characteristic taste and morphological features, making it to be considered as one of the popular herbal medicine. A scrutiny of literature revealed some notable pharmacological activities of the plant such as antidiabetic, hypolipidaemic, antimicrobial, free radical scavenging and anti-inflammatory role. This review attempts to encompass the available literature on Allium ampeloprasum with respect to its pharmacognostic characters, ethanobotanical and traditional uses, chemical constituents and summary of its various pharmacological activities and clinical effects
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    An overview of the effect of anionic coligand on structure and magnetic properties of some homometallic NiII and heterometallic NiII-MnII complexes of Schiff base ligands
    (ELSEVIER, 2024) Mandal, Subhra Kanti; Seth, Piya
    Homometallic NiII-Schiff base complexes with various anionic coligands have been widely studied for their structural diversity, catalytic and magnetic properties. Introduction of MnII as heterometal in these complexes is very much challenging to the synthetic and magneto-chemist as MnII possesses higher number of unpaired electrons in high spin ground state. Thus in NiII-MnII heterometallic polynuclear complexes spin–spin interaction and easy axis type magnetic anisotropy can lead to ferromagnetism, antiferromagnetism, ferrimagnetism, etc. In this dissertation we have discussed the synthetic strategies, structural features and magnetic properties of 20 homometallic NiII complexes and 13 heterometallic NiII-MnII complexes derived from some tridentate (N2O), tetradentate (N2O2) and hexadentate (N3O3) Schiff base ligands and various terminally coordinating or bridging anionic coligands (carboxylate, nitrate, nitrite, azide, thiocyanate, dicyanamide etc.). The profound role of anionic coligand in mediating phenoxido bridging angles and hence magnetic behavior of these complexes is also been highlighted.
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    Bibliometric study of the M.Phil. Dissertations in Library & Information Science awarded under the University of Calcutta during the period from 2004 to 2016
    (University of Nebraska - Lincoln, 2024-09-27) Chakrabarti, Kaustuv; Nishat, Nilofer; Kritania, Deep Kumar
    The purpose of this study is to attempt a bibliometric analysis of M.Phil. Dissertations awarded from Department of Library & Information Science, University of Calcutta. Total 136 M.Phil. dissertations were awarded covering the period from 2004 to 2016. These selected dissertations considered for the present study have been analyzed based on session wise distribution of dissertations and citations, guidance pattern and subject. The study shows the positive growth of dissertations in a number of areas and the most preferred research areas done on the topics are Community Information Services, Information Communication Technology and Bibliometrics.
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    Carbapenem Resistance in Clonally Distinct Clinical Strains of Vibrio fluvialis Isolated from Diarrheal Samples
    (Emerging Infectious Diseases, 2025-01-09) Chowdhury, Goutam; Pazhani, Gururaja Perumal; Sarkar, Anirban; Rajendran, Krishnan; Mukhopadhyay, Asish K.; Bhattacharya, Mihir K.; Ghosh, Amit; Ramamurthy, Thandavarayan R
    Carbapenems have been used for many years to treat severe nosocomial Enterobacteriaceae infections. The spread of resistance to these drugs among other bacterial families is an emerging problem worldwide, mostly caused by New Delhi metallo-β-lactamase (NDM-1). We screened for the prevalence of NDM-1–expressing enteric pathogens from hospitalized patients with acute diarrhea in Kolkata, India, and identified 27 Vibrio fluvialis–harboring blaNDM-1 (NDMVF) strains. These isolates were also resistant to all the tested antimicrobial drugs except doxycycline. The large plasmid of V. fluvialis harboring blaNDM-1 could be easily transferred to other enteric pathogens. Genes flanking the blaNDM-1 were found to be identical to the reported sequence from an Escherichia coli isolate. Analyses showed that the V. fluvialis possessing the NDM-VF region belonged to different clones. The pathogenicity of V. fluvialis to humans and its ubiquitous presence in the environment call for constant monitoring of this species for emerging antimicrobial drug resistance.
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    Classical Single Factor Optimisation of Parameters for Phenolic Antioxidant Extraction from Tamarind Seed (Tamarindus indica)
    (Horizon e-Publishing Group, 2025-01-04) Ghosh, Uma; Sarkar, Atreyi
    Presently the work deals with outreaching and exhaustive investigations involving single factor optimisation method, to optimise the parameters for phenolic antioxidant extraction from the seeds of Tamarindus indica. At first the characterization of the seeds has been performed by estimating the total calorie value, carbohydrate, protein, fat, Total Polyphenol Content (TPC), moisture (%), total ash (%), total solid (%), volatile solid (%), fixed carbon (%), bulk density (%), pH and solubility. The effects of solid to solvent ratio (1:10 - 1:30 w/v), ethanol concentration (25 - 100% v/v), extraction time (1 - 24 hours) and extraction temperature (25 - 60°C) have been investigated to optimise the extraction of Total Polyphenol Content (TPC) and Antioxidant capacity determined by Folin - Ciocalteu and FRAP analyses respectively. The solvent extraction conditions have been optimised at solid to solvent ratio of 1:20 w/v, 50% ethanol as solvent and 3 hours of shaking at 40°C.
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    Deubiquitination in prostate cancer progression: role of USP22
    (Journal of Cancer Metastasis and Treatment, 2024) Nag, Nivedita; Dutta, Samikshan
    Prostate cancer (PCa) is the leading cause of cancer death in men. With more therapeutic modalities available, the overall survival in PCa has increased significantly in recent years. Patients with relapses after advanced second- generation anti-androgen therapy however, often show poor disease prognosis. This group of patients often die from cancer-related complicacies. Multiple approaches have been taken to understand disease recurrence and to correlate the gene expression profile. In one such study, an 11-gene signature was identified to be associated with PCa recurrence and poor survival. Amongst them, a specific deubiquitinase called ubiquitin-specific peptidase 22 (USP22) was selectively and progressively overexpressed with PCa progression. Subsequently, it was shown to regulate androgen receptors and Myc, the two most important regulators of PCa progression. Furthermore, USP22 has been shown to be associated with the development of therapy resistant PCa. Inhibiting USP22 was also found to be therapeutically advantageous, especially in clinically challenging and advanced PCa. This review provides an update of USP22 related functions and challenges associated with PCa research and explains why targeting this axis is beneficial for PCa relapse cases.
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    Deubiquitination in prostate cancer progression: role of USP22
    (J Cancer Metastasis Treat, 2025-01-04) Dutta, Samikshan; Nag, Nivedita
    Prostate cancer (PCa) is the leading cause of cancer death in men. With more therapeutic modalities available, the overall survival in PCa has increased significantly in recent years. Patients with relapses after advanced second- generation anti-androgen therapy however, often show poor disease prognosis. This group of patients often die from cancer-related complicacies. Multiple approaches have been taken to understand disease recurrence and to correlate the gene expression profile. In one such study, an 11-gene signature was identified to be associated with PCa recurrence and poor survival. Amongst them, a specific deubiquitinase called ubiquitin-specific peptidase 22 (USP22) was selectively and progressively overexpressed with PCa progression. Subsequently, it was shown to regulate androgen receptors and Myc, the two most important regulators of PCa progression. Furthermore, USP22 has been shown to be associated with the development of therapy resistant PCa. Inhibiting USP22 was also found to be therapeutically advantageous, especially in clinically challenging and advanced PCa. This review provides an update of USP22 related functions and challenges associated with PCa research and explains why targeting this axis is beneficial for PCa relapse cases.
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    Effect of extraction temperature and technique on phenolic compounds and antioxidant activity of Tamarindus indica seeds
    (Research Journal of Recent Sciences, 2025-01-04) Sarkar, Atreyi; Ghosh, Uma
    Natural antioxidants from tamarind seed pose preservative effect in food and disease protective benefits in biological system. system Extraction being the initial and crucial most step of antioxidant recovery is influenced by many conditions. In this study theth effects fects of technique and temperature during solvent extraction of phenolic antioxidants from tamarind seed have been studied. The extraction techniques compared have been shaking and magnetic stirring. A binary solvent system of 50 % ethanol has been used andd extraction has been carried out at varied ttemperatures (ranging 25 - 60° C). Total Polyphenol Content (TPC) and Total Antioxidant Activity (TAA) determined at these conditions have indicated magnetic stirring as the most convenient and exhaustive technique. ue. While the maximum TPC has been extractable at 60° C, the highest TAA has been recorded at the extraction temperature of 40 ° C. Results have indicated that extracting temperature and technique significantly (P<0.05) influenced the antioxidant property and total phenolic compound recovery from tamarind seed.
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    ENCAPSULATION OPTIMIZATION OF TAMARIND SEED ANTIOXIDANTS IN ALGINATE HYDROGELS USING RESPONSE SURFACE METHODOLOGY: STUDY OF CONTROLLED RELEASE BEHAVIOR IN SIMULATED GASTROINTESTINAL CONDITIONS
    (2025-01-04) Sarkar, A.; Ghosh, U
    Tamarindus indica seeds - a byproduct of the foodindustry, are generated in huge amounts during tamarind pulp processing.These seeds are a source of a wide range of polyphenols with natural antioxidant content. In this study, we have encapsulated the polyphenolic components extracted from the seeds in an optimized condition. Statistical optimization of the encapsulation parameters was done using the central composite design of response surface methodology. The concentrations of sodium alginate (m:v, g ml -1), calcium chloride (m:v, g ml-1) and tamarind seed polyphenolic extract (m:v, g ml -1) were the independent variables whose direct and interaction effects were studied on the dependent variable or response of encapsulation efficiency. Further, the encapsulated beads were characterized by physical, chemical, morphological, radical quenching properties as well as textural characteristics. A higher percentage of polyphenols were recovered from beads in simulated gastric fluid, and the rest contents of polyphenols remaining inside the beads were found to be released in simulated intestinal fluid. The study was concluded with the remark that encapsulation of tamarind seed extracts in alginate could be a promising technique for supplementation in food with natural antioxidants.
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    FORTIFICATION OF DAIRY PRODUCT SHRIKHAND WITH NATURAL ANTIOXIDANT FROM THE EXTRACT OF TAMARIND SEED
    (Annals. Food Science and Technology, 2025-01-04) Sarkar, Atreyi; Ghosh, Uma
    Shrikhand- an Indian dairy based dessert is high in fat content, hence susceptible to derogatory oxidative changes. In food industry and also in home based preparations, antioxidant compounds are added to readily oxidisable foods. In food industries commercial synthetic antioxidant usage is very common, whereas scientific reports are emerging indicative of the toxicity of these kinds of antioxidants. However due to food safety issues and consumer’s preference on natural food ingredients, natural antioxidants are now being explored for food formulations. In this study antioxidant extracts from tamarind seed has been utilized in shrikhand. Functional, textural, physico chemical and organoleptic properties of the samples have been tested along with their changing profile over a 60 days storage period has also been monitored. The study has been concluded with the remarks that tamarind seed extract can be successfully utilized in food matrix as a source of natural antioxidant
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    FORTIFICATION OF DAIRY PRODUCT SHRIKHAND WITH NATURAL ANTIOXIDANT FROM THE EXTRACT OF TAMARIND SEED
    (2024-11-11) Sarkar,Atreyi; Ghosh, Uma
    Shrikhand- an Indian dairy based dessert is high in fat content, hence susceptible to derogatory oxidative changes. In food industry and also in home based preparations, antioxidant compounds are added to readily oxidisable foods. In food industries commercial synthetic antioxidant usage is very common, whereas scientific reports are emerging indicative of the toxicity of these kinds of antioxidants. However due to food safety issues and consumer’s preference on natural food ingredients, natural antioxidants are now being explored for food formulations. In this study antioxidant extracts from tamarind seed has been utilized in shrikhand. Functional, textural, physico chemical and organoleptic properties of the samples have been tested along with their changing profile over a 60 days storage period has also been monitored. The study has been concluded with the remarks that tamarind seed extract can be successfully utilized in food matrix as a source of natural antioxidant.
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    Molecular Basis of Root Nodule Symbiosis between Bradyrhizobium and ‘Crack-Entry’ Legume Groundnut (Arachis hypogaea L.)
    (MDPI, 2024) Sharma, Vinay; Bhattacharyya, Samrat; Kumar, Rakesh; Kumar, Ashish; Ibañez, Fernando; Wang, Jianping; Guo, Baozhu; Sudini, Hari K; Gopalakrishnan, Subramaniam; DasGupta , Maitrayee; Varshney, Rajeev K.; Pandey, Manish K.
    Nitrogen is one of the essential plant nutrients and a major factor limiting crop productivity. To meet the requirements of sustainable agriculture, there is a need to maximize biological nitrogen fixation in different crop species. Legumes are able to establish root nodule symbiosis (RNS) with nitrogen-fixing soil bacteria which are collectively called rhizobia. This mutualistic association is highly specific, and each rhizobia species/strain interacts with only a specific group of legumes, and vice versa. Nodulation involves multiple phases of interactions ranging from initial bacterial attachment and infection establishment to late nodule development, characterized by a complex molecular signalling between plants and rhizobia. Characteristically, legumes like groundnut display a bacterial invasion strategy popularly known as “crack-entry” mechanism, which is reported approximately in 25% of all legumes. This article accommodates critical discussions on the bacterial infection mode, dynamics of nodulation, components of symbiotic signalling pathway, and also the effects of abiotic stresses and phytohormone homeostasis related to the root nodule symbiosis of groundnut and Bradyrhizobium. These parameters can help to understand how groundnut RNS is programmed to recognize and establish symbiotic relationships with rhizobia, adjusting gene expression in response to various regulations. This review further attempts to emphasize the current understanding of advancements regarding RNS research in the groundnut and speculates on prospective improvement possibilities in addition to ways for expanding it to other crops towards achieving sustainable agriculture and overcoming environmental challenges.
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    Natural Antioxidants - The Key to Safe and Sustainable Life
    (International Journal of Latest Trends in Engineering and Technology, 2025-01-04) Sarkar, Atreyi
    This review work analytically explicates the food sources, chemistry and benefits of natural antioxidants. Naturally occurring antioxidants are not only capable of abolishing the ill effects of free radical damage to food system, but their consumption also boost the body’s endogenous antioxidant mechanism to combat oxidative stress. Natural ingredients in food are gaining much contemplation in both the areas of food industry and research, as these are considered safer option than synthetic additives. This review explores the possible uses of natural antioxidants as additive and components of functional food formulations. Critical analysis of natural antioxidants as additive in food is reviewed, addressing food safety and health benefit for the consumers.
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    Optimization of the extraction of natural phenolic antioxidants from the seeds of Tamarindus indica L. - an undervalued by product of food processing - using response surface methodology
    (Acta Biologica Szegediensis, 2025-01-04) Sarkar, Atreyi; Ghosh, Uma
    Optimization of the extraction of natural phenolic antioxidants from the seeds of Tamarindus indica L. - an undervalued by product of food processing - using response surface methodology Atreyi Sarkar, Uma Ghosh* Department of Food Technology and Biochemical Engineering, Jadavpur University, Jadavpur, Kolkata - 700032, India The seeds of Tamarindus indica are known to possess a wide range of phenolic compounds with high antioxidant activity as measured by the ferric reducing antioxidant power (FRAP). In the present study, the optimum conditions for the extraction of crude phenolic antioxidants from Tamarind seed were determined using response surface methodology (RSM). A central composite design (CCD) was used to investigate the effects of four independent variables, namely concentration of extractable solids in solvent (g/ml; X1), extraction time (h; X2), extraction temperature (°C; X3) and solvent concentration (%, v/v; X4) on the responses of total polyphenol content (TPC) and FRAP. The CCD consisted of 30 experimental runs. A second-order polynomial model was used for predicting the responses. Canonical analysis of the surface responses revealed that the predicted optimal conditions for the maximal yield of TPC and FRAP were concentra-tion of extractable solids in solvent of 0.049 g/ml, extraction time of 3.24 h, extraction temperature of 45 °C and a solvent concentration of 50%. The experimental values in the optimised condition coincided with the predicted ones within a 95% confidence interval, hence indicating the suitability of the model and the success of RSM in optimizing the extraction parameters.
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    Overview on the New Delhi Metallo- -Lactamase (NDM)-producers
    (2025-01-09) Ghosh, Amit; Sarkar, Anirban; CHOWDHURY, GOUTAM; PAZHANI, GURURAJA PERUMAL; RAMAMURTHY, THANDAVARAYAN
    New -lactamases with ever-broadening substrate specificity are disseminating rapidly all over the world. In the recent years, extent of resistance of human pathogens to -lactam antibiotics is increasing due to the emergence of “new” carbapenemase-producers. New Delhi metallo- -lactamase (NDM) is the latest carbapenemase, detected for the first time during 2008, in bacteria isolated from patients epidemiologically linked to the Indian subcontinent. Apart from carbapenems, NDM-producers are often resistant to other clinically useful antimicrobials such as aminoglycosides and fluoroquinolones. Although the main type of NDM is NDM-1, nine variants have been identified till to date. NDM enzymes have been detected mainly in genetically heterogeneous members of the Enterobacteriaceae family and recently in non-fermenters and Vibrionaceae. The gene blaNDM-1 is located on plasmids of heterogeneous nature of varying sizes and is transferable to a wide range of microbes. Although several methods for the detection of NDM-producers exist, modified Hodge test and the detection of blaNDM-1 by PCR are generally used. Antimicrobials polymyxins (colistin) and glycylcyclines (tigecyclines) show promising activity against NDM-producers in vitro, but there is dispute on their clinical use for safety issues. For preventing the spread of NDM-producers, it is essential to have proper surveillance system in place and for its containment, emphasis should be on research to develop new and safe antimicrobials active against these bugs. In this review, an overview of all these aspects has been presented.